Tuesday, 30 July
Covance Exhibitor Showcase

 

The Advantages of Using Radiolabelled Test Materials in ADMET

Speaker: Guy Webber, Scientific Manager for In Vitro and Drug-Drug Interaction Sciences

Time: 12:30 - 13:00

Educational Needs Statement: This session is intended to advise the audience on some of the important aspects to consider when planning a custom radiosynthesis of a new test molecule and how to consider maximizing its applicability to aid drug development.

Learning Objectives:

  • The major considerations when planning a custom radiosynthesis of a test molecule.

  • How to maximize the usefulness of this valuable, but limited, material.

Who Should Attend?

  • Scientists in Pharma and Biotech R&D involved with pre-clinical drug development, particularly those working in DMPK and ADMET.

Abstract:

Participants will gain a deeper understanding of the varied DMPK and ADMET studies where having a radiolabelled form of a test molecule offers numerous advantages compared to non-radiolabelled approaches including MIST strategies, DDI Phenotyping and Transporter studies and aspects of DILI assessment. The talk will also consider some of the major considerations that need to be considered when planning a custom radiosynthesis including choice of radionuclide, reaction yields, radiochemical purity and stability and amount of material required for typical studies.